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Scientist I, Bioconjugation, GI DDU

Company: Takeda Pharmaceutical
Location: Santee
Posted on: August 5, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as a Scientist I where you will conduct preclinical research and development in the area of bioconjugation. You will contribute to the design and synthesis of bioconjugates and development of conjugation protocol. As part of the GI Chemistry Team, you will report to the Senior Scientist, Medicinal Chemistry and work with the Gastroenterology Drug Discovery Unit (GI DDU), driving deliverables to meet project needs using both internal and external resources. How you will contribute:

  • Manage bioconjugation efforts internally and at external contract research organizations (CROs) including project tracking, building chemistry plans, compound management, troubleshooting, evaluation and analysis of data.
  • Develop and optimize conjugation protocols using novel chemistries and technologies.
  • Drive and contribute to the bioconjugation function for one or more drug discovery projects, working in close collaboration with partners including in vitro and in vivo pharmacology, computational chemistry, DMPK, structural biology and other key functions.
  • Manage external partners to ensure deliverables meet project needs and timelines.
  • Demonstrate excellent organizational skills to support the achievement of key goals under strict timelines. Minimum Requirements/Qualifications:
    • Ph.D. in Organic Chemistry / Biochemistry / Chemical Biology or other relevant discipline
    • MS with 6+ years experience, or
    • BS with 8+ years experience
    • Experience in the design, synthesis, purification and characterization of protein bioconjugates.
    • Experience with antibody, oligonucleotide and/or peptide bioconjugation, including dye conjugation, is preferable.
    • Experience in one or more of the following protein characterization / purification techniques: ultraviolet spectroscopy (UV), ion exchange (IEX), size exclusion (SEC), hydrophobic interaction chromatography (HIC), reversed-phase HPLC (RP-HPLC), liquid chromatography-mass spectrometry (LC-MS) and gel electrophoresis (SDS-PAGE); additional oligonucleotide and peptide purification experience is also desirable.
    • Experience with bioconjugate SAR (linker optimization, potency, stability), protein / antibody drug discovery and targeted delivery desirable.
    • Up-to-date knowledge of the field and key technology advancements preferable. What Takeda can offer you:
      • Comprehensive Healthcare: Medical, Dental, and Vision
      • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach Programs and company match of charitable contributions
      • Family Planning Support
      • Flexible Work Paths
      • Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, Santee , Scientist I, Bioconjugation, GI DDU, Other , Santee, California

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