Director / Sr. Director - Computational Peptide Design

Company: Society for Conservation Biology
Location: San Diego
Posted on: May 20, 2025

Job Description:

Employer: Eli Lilly and CompanyLocation: San Diego, California, USSalary: CompetitiveClosing date: May 14, 2025Sector: Academic / ResearchField: Informatics / GISDiscipline: ModelingJob Level: Senior levelSalary Type: SalaryEmployment Type: Full timeAt Lilly, we unite caring with discovery to improve lives globally. Headquartered in Indianapolis, Indiana, our employees work to discover life-changing medicines, understand and manage diseases, and support communities through philanthropy and volunteerism. We prioritize putting people first and strive to make life better for all.Our Biotechnology Discovery Research (BioTDR) organization has a proven track record in delivering novel biotherapeutic medicines into clinical research, focusing on unmet medical needs across various therapeutic areas. We integrate biology with cutting-edge scientific capabilities in peptide discovery, engineering, and computational science to deliver next-generation peptide therapeutics.We are seeking a senior-level computational peptide scientist to develop innovative technologies that accelerate peptide discovery and design. Located at the Lilly Biotechnology Center in San Diego, this role involves leading a small team and developing complex workflows and pipelines for peptide selection, design, and optimization. Collaborating with multidisciplinary teams and leveraging advanced technologies, you will contribute to groundbreaking peptide therapies. If passionate about computational innovation in peptide drug discovery, we encourage you to apply.Primary Responsibilities:

• Lead the design of bespoke peptide libraries using advanced computational techniques, including bio-/chem-informatics and AI/ML.
• Develop informatics tools for NGS data visualization and processing to facilitate peptide hit selection.
• Create computational methods to improve peptide SAR, activity, selectivity, stability, and permeability.
• Implement advanced computational methods for peptide modeling and optimization, leveraging AI/ML for predictive modeling.
• Collaborate with peptide groups and multidisciplinary teams to integrate computational strategies in peptide discovery and optimization.
• Manage codebase and model repositories to ensure reproducibility and collaboration.
• Stay updated with AI/ML advancements and drive their application in peptide research.
• Present scientific findings and strategies to internal and external stakeholders.Basic Qualifications:
  • Ph.D. in Computational Chemistry, Biology, Chemistry, Physics, or a related field.
  • Minimum of 5 years of relevant experience beyond education/postdoctoral training; 10+ years preferred.Additional Skills and Preferences:
    • Expertise in NGS bioinformatics and computational peptide design.
    • Experience with cheminformatics, non-canonical amino acids, and peptide library design.
    • Proficiency in sequence- and physics-based computational tools (e.g., MOE, Schrodinger, Rosetta).
    • Experience in molecular modeling techniques and ML/AI applications in peptides.
    • Programming skills (Python) for data analysis and metric development.
    • Proven leadership in computational peptide discovery projects.
    • Experience managing and developing scientific teams.
    • Knowledge of cloud and high-performance computing environments.
    • Excellent communication and collaboration skills.Additional information about location, accommodations, diversity policies, employee resource groups, compensation, and benefits is provided in the original description.
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Keywords: Society for Conservation Biology, Santee , Director / Sr. Director - Computational Peptide Design, Executive , San Diego, California