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Associate Director - Quantitative Systems Pharmacology Modeler

Company: Takeda Pharmaceutical
Location: Santee
Posted on: May 13, 2022

Job Description:

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Job Description
Associate Director, Quantitative Systems Pharmacology Modeler
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Associate Director, Systems Pharmacology Modeler in our Cambridge, MA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

POSITION OBJECTIVES:
The Quantitative Solutions department of Takeda Pharmaceuticals is seeking a mechanistic modeler to support global drug development by building models for novel therapeutic agents to treat various gastrointestinal diseases including liver disease and diseases that result from abberant immune activation within the gut. The successful candidate will collaborate with preclinical research and drug discovery, DMPK, clinical pharmacology, clinical research, nonclinical drug safety, translational medicine and pharmacovigilance to develop mathematical models to understand the targeted biological pathways and exposure-response/safety relationship of novel therapeutic agents. The candidate will also be responsible for implementing the right modeling & simulation strategy to assist with drug development, establish PK/PD relationships and create mechanistic pharmacology/toxicology models to support project needs. Essential qualifications include in-depth understanding of biochemistry, immunology, numerical methods, as well as hands-on experience with modeling software, and ability to clearly present modeling and simulation findings.
POSITION ACCOUNTABILITIES:
This is an exciting opportunity at the interface between clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism, translational medicine and pharmacovigilance to influence drug development. The candidate is expected to design and build translational PK/PD and mechanistic or platforms models to assist with safety margin selection, study design and biomarker selection
EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
Ph.D/Pharm.D/M.D with training in chemical or biomedical engineering, pharmaceutical sciences, mathematics, statistics, or equivalent area with at least 7 years of post-graduate industry or academic experience in mathematical modeling of biological systems. Job title is flexible based on experience. Strong competency in coding and running modeling and simulation related software such as Matlab, NONMEM, Phoenix Winnonlin and R is required. Publication(s) applying modeling and simulation approaches to gastrointestinal diseases and immunology is preferred. Proficiency with systems modeling approaches such as differential equation, logic, stochastic, agent-based, or other advanced mechanistic modeling approaches is essential. Demonstrated ability for critical thinking and strong analytical skills to evaluate complex information to identify key scientific questions related to projects. Ability to prioritize and manage multiple projects while meeting project deadlines.
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan Tuition reimbursement Company match of charitable contributions Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs
Empowering Our People to Shine

Discover more at takedajobs.com

No Phone Calls or Recruiters Please.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
#LI-KB

EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations
Boston, MA

San Diego, CA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time

Keywords: Takeda Pharmaceutical, Santee , Associate Director - Quantitative Systems Pharmacology Modeler, Executive , Santee, California

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